Lower Linkage Disequilibrium at CNVs is due to Both Recurrent Mutation and Transposing Duplications
نویسندگان
چکیده
منابع مشابه
Lower linkage disequilibrium at CNVs is due to both recurrent mutation and transposing duplications.
Copy number variants (CNVs) within humans can have both adaptive and deleterious effects. Because of their phenotypic significance, researchers have attempted to find single nucleotide polymorphisms (SNPs) in high linkage disequilibrium (LD) with CNVs to use in genomewide association studies. However, studies have found that CNVs are less likely to be in strong LD with flanking markers. We hypo...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2009
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msp210